First 3D structure of human γ-secretase determined by cryo-EM at 4.5 Å resolution

First 3D structure of human γ-secretase determined by cryo-EM at 4.5 Å resolution
Lu, P.; Bai, X.; Ma, D.; Xie, T.; Yan, C.; Sun, L.; Yang, G.; Zhao, Y.; Zhou, R.; Scheres, S. H.; Shi, Y.

GPU Reconstruction Palette

GPU Reconstruction Palette

GPU Reconstruction software palette

Colorized EELS elemental map

Colorized EELS elemental map
This work was performed in collaboration with Dr. Phil Rice and Dr. Teya Topuria of IBM Almaden Research Center in San Jose, CA who provided expert assistance as well as the TEM specimen and access to their microscope facilities.

Colorized EELS elemental map of Ti L2,3-edges at 456 eV (green), Mn L2,3-edges at 640 eV (blue), La M4,5-edges at 832 eV (purple) and Sr L2,3-edges at 1940 eV (red).

Murano heating stage

Recrystallization observation of bronze specimen

EBSD map of bronze specimen recrystallization taken in-situ at 800 °C using Murano™ heating stage.

CF302M Liquid helium cooling stage

CF302M Liquid helium cooling stage

CF302 Liquid Helium Cooling Stage

CF302 Liquid Helium Cooling Stage

C1010 Airlock

C1010 Airlock

C1003 Nitrogen cooling stage

C1003 Nitrogen cooling stage

C1002 Nitrogen cooling stage

C1002 Nitrogen cooling stage

C1001 Nitrogen cooling stage

C1001 Nitrogen cooling stage

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