COVID Research
Much of the early work in cryo-EM was focused on solving the 3D structure of important viruses. With the new coronavirus structure in the headlines, we thought it would be helpful to point out a number of the structural biologists whose work has contributed to the rapid pace of research on coronaviruses.
We would like to congratulate all the researchers for their tremendous efforts. The Gatan team takes great pride in the instrumentation that helps to accelerate this research.
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape
Science - January 12, 2021
Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM
Science Advances - January 1, 2021
They spent 12 years solving a puzzle. It yielded the first COVID-19 vaccines.
National Geographic - December 31, 2020
Coronavirus infection induces progressive restructuring of the endoplasmic reticulum involving the formation and degradation of double membrane vesicles
Science Direct - December 24, 2020
Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains
Solved with the Latitude S® software and the BioQuantum™ K3® System
Science Direct - December 9, 2020
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive spike
Solved with the BioQuantum K3 System
Science - November 5, 2020
In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges
Solved with the BioQuantum K3 System
Science - October 9, 2020
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
Science - September 18, 2020
SARS-CoV-2 Nsp1 binds the ribosomal mRMA channel to inhibit translation
Nature Structural & Molecular Biology - September 9, 2020
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction
Nature Communications - September 4, 2020
Molecular architecture of the SARS-CoV-2 virus
Cell - September 3, 2020
SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography
bioRxiv - August 16, 2020
Distinct conformational states of SARS-CoV-2 spike protein
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Structures, conformations, and distributions of SARS-CoV-2 spike protein trimers on intact virions
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Potent neutralizing monoclonal antibodies directed to multiple epitopes on the SARS-CoV-2 spike
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Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody
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Structure of the RNA-dependent RNA polymerase from COVID-19 virus
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Structure of the RNA-dependent RNA polymerase from COVID-19 virus
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What the structure of the coronavirus can tell us Understanding the coronavirus structure is important to build an effective vaccine or therapeutic.
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Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
Prepared with the Solarus® Plasma Cleaner and solved with the K3 Direct Detection Camera
Press release – February 19, 2020
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BioContinuum System
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K3 Direct Detection Camera
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Elsa™ Cryo-Holder
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Solarus II Plasma Cleaner
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Latitude® S Software
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