Gatan salutes all the scientists at the cutting edge of coronavirus research

Much of the early work in cryo-EM was focused on solving the 3D structure of important viruses. With the new coronavirus structure in the headlines, we thought it would be helpful to point out a number of the structural biologists whose work has contributed to the rapid pace of research on coronaviruses.

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COVID-19

What the structure of the coronavirus can tell us
Wahington Post article - March 23, 2020

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2
Solved with the K3™ Direct Detection Camera
March 4, 2020

Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein
Solved with the K2® Camera
Press release – February 21, 2020

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation 
Prepared with the Solarus® Plasma Cleaner and solved with the K3™ Direct Detection Camera
Press release – February 19, 2020

SARS

Structural basis for human coronavirus attachment to sialic acid receptors – 2.8 Å
SARS-Coronavirus NSP12 bound to NSP7 and NSP8 co-factors – 3.1 Å

MERS

MERS-CoV S structure in complex with 5-N-acetyl neuraminic acid 2.5 Å
MERS-CoV S structure in complex with 2,3-sialyl-N-acetyl-lactosamine 2.7 Å
MERS-CoV S structure in complex with sialyl-lewisX 2.8 Å
MERS-CoV complex with human neutralizing LCA60 antibody Fab fragment (state 1) – 3.5 Å
MERS-CoV S complex with human neutralizing LCA60 antibody Fab fragment (state 2) 3.6 Å
MERS S0 trimer in complex with antibody G2 4.19 Å

We would like to congratulate all the researchers for their tremendous efforts. The Gatan team takes great pride in the instrumentation that helps to accelerate this research.