The versatile K3 IS direct detection camera is allowing for in-situ characterization of material reactions with high ease-of-use and unhindered switching between low-dose and high-speed imaging. The large field of view with the K3 IS camera has enabled investigations on nanoparticle transformations and dynamics at temperature within the environmental TEM, lithiation of battery anodes, and 4D STEM strain mapping of nanowires post in-situ testing.