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Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies

Cell
2020

Barnes, C. O.; West Jr., A. P.; Huey-Tubman, K. E.; Hoffmann, M. A. G.; Sharaf, N. G.; Hoffman, P. R.; Koranda, N.; Gristick, H. B.; Gaebler, C.; Muecksch, F.; Lorenzi, J. C. C.; Finkin, S.; Hägglöf, T.; Hurley, A.; Millard, K. G.; Weisblum, Y.; Schmidt, F.; Hatziioannou, T.; Bieniasz, P. D.; Caskey, M.; Robbiani, D. F.; Nussenzweig, M. C.; Bjorkman. P. J.

Potent neutralizing antibodies against SARS-CoV-2 identified by high-throughput single-cell sequencing of convalescent patients’ B cells

Cell
2020

Cao, Y.; Su, B.; Guo, X.; Sun, W.; Deng, Y.; Bao, L.; Zhu, Q.; Zhang, X.; Zheng, Y.; Geng, C.; Chai, X.; He, R.; Li, X.; Lv, Q.; Zhu, H.; Deng, W.; Xu, Y.; Wang, Y.; Qiao, L.; Tan, Y.; Song, L.; Wang, G.; Du, X.; Gao, N.; Liu, J.; Xiao, J.; Su, X. -D.; Du, Z.; Feng, Y.; Qin, C.; Qin, C.; Jin, R.; Xie, X. S.

Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein

Cell
2020

Walls, A. C.; Park, Y. -J.; Tortorici, M. A.; Wall, A.; McGuire, A. T.; Veesler, D.

Cryo-EM structure of an extended SARS-CoV-2 replication and transcription complex reveals an intermediate state in cap synthesis

Cell
2021

Yan, L.; Ge, J.; Zheng, L.; Zhang, Y.; Gao, Y.; Wang, T.; Huang, Y.; Yang, Y.; Gao, S.; Li, M.; Liu, Z.; Wang, H.; Li, Y.; Chen, Y.; Guddat, L. W.; Wang, Q.; Rao, Z.; Lou, Z.

Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex

Cell
2020

Chen, J.; Malone, B.; Llewellyn, E.; Grasso, M.; Shelton, P. M. M.; Olinares, P. D. B.; Maruthi, K.; Eng, E. T.; Vatandaslar, H.; Chait, B. T.; Kapoor, T. M.; Darst, S. A.; Campbell, E. A.

Structurally resolved SARS-CoV-2 antibody shows high efficacy in severely infected hamsters and provides a potent cocktail pairing strategy

Cell
2020

Du, S.; Cao, Y.; Zhu, Q.; Yu, P.; Qi, F.; Wang, G.; Du, X.; Bao, L.; Deng, W.; Zhu, H.; Liu, J.; Nie, J.; Zheng, Y.; Liang, H.; Liu, R.; Gong, S.; Xu, H.; Yisimayi, A.; Qin, C.

Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2

Cell Discovery
2020

Wu, L.; Chen, Q.; Liu, K.; Wang, J.; Han, P.; Zhang, Y.; Hu, Y.; Meng, Y.; Pan, X.; Qiao, C.; Tian, S.; Du, P.; Song, H.; Shi, W.; Qi, J.; Wang, H. -W.; Yan, J.; Gao, G. F.; Wang, Q.

Neutralization of SARS-CoV-2 by destruction of the prefusion spike

Cell Host & Microbe
2020

Huo, J.; Zhao, Y.; Ren, J.; Zhou, D.; Duyvesteyn, H. M. E.; Ginn, H. M.; Carrique, L.; Malinauskas, T.; Ruza, R. R.; Shah, P. N. M.; Tan, T. K.; Rijal, P.; Coombes, N.; Bewley, K. R.; Tree, J. A.; Radecke, J.; Paterson, N. G.; Supasa, P.; Mongkolsapaya, J.; Screaton, G. R.; Carroll, M.; Townsend, A.; Fry, E. E.; Owens, R. J.; Stuart, D. I.

Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition

Cell Host & Microbe
2021

Greaney, A. J.; Starr, T. N.; Gilchuk, P.; Zost, S. J.; Binshtein, E.; Loes, A. N.; Hilton, S. K.; Huddleston, J.; Eguia, R.; Crawford, K. H. D.; Dingens, A. S.; Nargi, R. S.; Sutton, R. E.; Suryadevara, N.; Rothlauf, P. W.; Liu, Z.; Whelan, S. P. J.; Carnahan, R. H.; Bloom, J. D.

Cryo-EM structures of SARS-CoV-2 spike without and with ACE2 reveal a pH-dependent switch to mediate endosomal positioning of receptor-binding domains

Cell Host & Microbe
2020

Zhou, T.; Tsybovsky, Y.; Gorman, J.; Rapp, M.; Cerutti, G.; Chuang, G. -Y.; Katsamba, P. S.; Sampson, J. M.; Schön, A.; Bimela, J.; Boyington, J. C.; Nazzari, A.; Olia, A. S.; Shi, W.; Sastry, M.; Stephens, T.; Stuckey, J.; Teng, I. -T.; Kwong, P. D

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