
Dose fractionation and motion correction
September 17, 2019
Optimized for cryo-EM and cryo-ET to gain further insight into system function and disease progression at the molecular level.

BioContinuum® is a post-column imaging filter that improves the contrast of transmission electron microscope (TEM) images and delivers the most powerful imaging performance in life science applications.
The BioContinuum combines the latest generation of GIF electron optics with the K3® camera's transformative direct detection technology. This powerful combination of energy filter and camera is optimized for cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET). With the BioContinuum you can successfully gain insight into the atomic structure of biological macromolecules and disease progression at the molecular level.
Providing the most easy-to-use and versatile system, the BioContinuum imaging filter can be controlled by the powerful DigitalMicrograph® software including Latitude® S, Latitude T, and Latitude D. Alternatively, the BioContinuum imaging filter can be integrated into Thermo Scientific EPU software, Thermo Scientific Tomography software, Serial EM, and Leginion.
The BioContinuum imaging filter is available in two different models:
BioContinuum | BioContinuum HD | |
|---|---|---|
| Model number | 1067 | 1067HD |
| Detector | K3 | K3 |
| Real-time motion correction | Optional | Optional |
| Integrated centered beam stop | Optional | Optional |
| EELS capability | – | Optional |
| EFTEM capability | – | Optional |
| Integrated BF/DF detector for STEM imaging | – | Optional |
The BioContinuum HD imaging filter is compatible with most TEMs from Thermo Fisher, JEOL, and Hitachi.
Easy to use
High-quality, high-throughput direct detection imaging
Stable, aberration-corrected optics
Versatile upgrade path
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