Cryo EM reveals mechanisms of gating and drug modulation in 5 HT3A receptors webinar

The serotonin 5-HT3 receptor antagonists or 'setrons' are the most common therapeutics to manage the side effects of chemotherapy and IBS. This webinar explored the single-particle cryo-electron microscopy research of Dr. Sudha Chakrapani, Director of Cryo Electron Microscopy Core, and the Cleveland Center for Membrane and Structural Biology. Results were presented of recently solved structures of the full-length 5HT3AR in the resting state, in serotonin-activated conformations, and in complex with several clinically used drugs.