Nature Methods has named Cryo-EM as Method of the Year, 2015

January 08, 2016

Gatan would like to congratulate all of the scientists and researchers whose hard work has contributed to Nature Methods declaring cryo-EM as the 2015 Method of the Year. We are proud to be a part of the community and are also pleased that the K2 Summit® direct detection camera and the GIF Quantum® LS imaging filter from Gatan have been a part of the tremendous technological improvement in cryo-EM.

Cryo-EM is an increasingly popular technique used by structural biologists to solve structures at atomic resolution. This technique complements x-ray crystallography because it reveals structural details without the need for a crystalline specimen. Through the examination of a frozen-hydrated specimen in vitreous (non-crystalline) ice, the specimen ultrastructure, buffer and ligand distribution from its native state are maintained. Cryo-EM also complements structural studies using nuclear magnetic resonance (NMR) in that it enables the study of specimens larger than 150 kDa. Structural biologists frequently use cryo-EM to study viruses, small organelles, and macromolecular biological complexes, as well as molecular interactions in supramolecular assemblies or machines. To learn more about the technique, please visit our Cryo-EM technique page.

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