BioContinuum Imaging Filter

Optimized for cryo-EM and cryo-ET to gain further insight into system function and disease progression at the molecular level.

Advantages Research Spotlight Media Library Publications Resources Back to top

The BioContinuum™ imaging filter combines the latest generation in electron optics with a transformative direct detection system that streamlines single-particle imaging and studies of cellular organization and ultrastructure. Ideally suited for low-dose imaging applications, the BioContinuum is optimized for cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) to gain further insight into system function and disease progression at the molecular level.

  • Highest DQE available: Confidently detect smaller particles, distinguish conformational changes, perform cryo-ET at a lower dose, and preserve higher-resolution information for 3D reconstruction
  • Intelligent tuning: Use smart algorithms to speed up and streamline optics alignment for both novice and expert users
  • Most stable optics in the market: Extremely stable ZLP positioning offers consistent data quality with no downtime in imaging 

  • Lowest image distortion: Utilize the Continuum’s cutting-edge optics to reduce image distortion while maximizing the available imaging area with the K3 direct detector
  • 1,500 full frames per second: Acquire 3.75 times the speed of the GIF Quantum® LS imaging filter
  • 24-megapixels field of view: Capture 1.6 times the size of the GIF Quantum® LS imaging filter
  • EELS and EFTEM compatible: Add electron energy loss spectroscopy (EELS) and energy-filtered transmission electron microscopy (EFTEM) support to expand the functionality of the BioContinuum HD



Model 1067


BioContinuum Imaging Filter

Related products

K3® Direct Detection Camera
Latitude® S Software
Elsa™ Cryo-Transfer Holder

Related materials

Nyquist frequency
Dose fractionation and motion correction
Improving DQE with counting and super-resolution

Modulation transfer function (MTF) curves
  200 kV 300 kV


Standard Standard







Continuing our prosperous collaborations that built the K2, the K3 is the successful result of Peter Denes' team at Lawrence Berkeley National Laboratory and David Agard.

Back to top