BioContinuum Imaging Filter

The BioContinuum™ imaging filter combines the latest generation in electron optics with a transformative direct detection system that streamlines single-particle imaging and studies of cellular organization and ultrastructure. Ideally suited for low-dose imaging applications, the BioContinuum is optimized for cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) to gain further insight into system function and disease progression at the molecular level.

• Highest DQE available: Confidently detect smaller particles, distinguish conformational changes, perform cryo-ET at a lower dose, and preserve higher-resolution information for 3D reconstruction
• Intelligent tuning: Use smart algorithms to speed up and streamline optics alignment for both novice and expert users
• Most stable optics in the market: Extremely stable ZLP positioning offers consistent data quality with no downtime in imaging 

• Lowest image distortion: Utilize the Continuum’s cutting-edge optics to reduce image distortion while maximizing the available imaging area with the K3 direct detector
• 1,500 full frames per second: Acquire 3.75 times the speed of the GIF Quantum^® LS imaging filter
• 24-megapixels field of view: Capture 1.6 times the size of the GIF Quantum^® LS imaging filter
• EELS and EFTEM compatible: Add electron energy loss spectroscopy (EELS) and energy-filtered transmission electron microscopy (EFTEM) support to expand the functionality of the BioContinuum HD