BioContinuum Imaging Filter

Optimized for cryo-EM and cryo-ET to gain further insight into system function and disease progression at the molecular level.

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Advantages: 

BioContinuum™ delivers the most powerful imaging performance in the life sciences sector. The BioContinuum imaging filter combines the latest generation electron optics with K3® camera's transformative direct detection technology that streamlines single-particle imaging and studies of cellular organization and ultrastructure at low electron dose. Ideally suited for low-dose imaging applications, the BioContinuum is optimized for cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) to gain further insight into system function and disease progression at the molecular level.

  • Highest detective quantum efficiency (DQE): Image smaller particles with high contrast at a lower dose
  • Highest imaging throughput available in the market: Collect high-quality cryo-EM datasets in a fraction of time (6 – 20 times faster) as compared to the leading competition
  • Intelligent tuning: Smart algorithms allow ultra-fast zero-loss peak (ZLP) centering and filter tuning for both novice and expert users
  • Most stable optics in the market: Extremely stable ZLP positioning offers consistent data quality with no downtime in imaging 

  • Lowest image distortion: Utilize the Continuum’s cutting-edge optics to reduce image distortion while maximizing the available imaging area with the K3 direct detector
  • 1,500 full frames per second: Acquire 3.75 times the speed of the GIF Quantum® LS imaging filter
  • 24-megapixels field of view: Capture 1.6 times the size of the GIF Quantum® LS imaging filter

Resources:

 

Model 1067

Datasheet

BioContinuum Imaging Filter

Related products

K3™ Direct Detection Camera
Latitude™ S Software
Elsa™ Cryo-Transfer Holder

Related materials

Nyquist frequency
Dose fractionation and motion correction
Improving DQE with counting and super-resolution

Modulation transfer function (MTF) curves
  200 kV 300 kV

K3

CDS CDS
Standard Standard

 

 

 

 

 

Acknowledgment

Continuing our prosperous collaborations that built the K2, the K3 is the successful result of Peter Denes' team at Lawrence Berkeley National Laboratory and David Agard.

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